Pulmonary Arterial Hypertension and Obesity†
Wendell H. Williams III1, Robert E. Safford2, Michael G. Heckman3, Julia E. Crook3, Charles D. Burger*, 1
Identifiers and Pagination:Year: 2010
First Page: 132
Last Page: 136
Publisher Id: TOOBESJ-2-132
Article History:Received Date: 05/01/2010
Revision Received Date: 16/06/2010
Acceptance Date: 18/06/2010
Electronic publication date: 23/9/2010
Collection year: 2010
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
To examine the association between obesity and pulmonary arterial hypertension (PAH). Methods: This retrospective case-control study consisted of patients with PAH (N=207) and controls seen at a pulmonary clinic for reasons other than PAH (N=965). All patients were evaluated between 1992 and 2006 at Mayo Clinic in Jacksonville, Florida. Obesity was defined as body mass index (BMI) of 30 kg/m2 or higher; class II obesity was defined as a BMI between 35.0 and 39.9 kg/m2, and class III obesity was defined as a BMI of 40.0 kg/m2 or higher.
Obesity was present in 63 patients with PAH (30%) and 290 controls (30%). Class II or III obesity was present in 34 patients with PAH (16%) and 103 controls (11%), while class III obesity was present in 16 patients with PAH (8%) and 36 controls (4%). After adjustment for age, sex, and thyroid disease in logistic regression analysis, an association between obesity and PAH was not evident (odds ratio [OR], 0.97; P=.87), however non-statistically significant trends were observed toward an association between PAH and class II or III obesity (OR, 1.40; P=.14) and class III obesity (OR, 1.70; P=.11).
Our findings do not indicate an association between PAH and obesity in WHO diagnostic group 1 patients. However trends were observed toward more severe class II and III obesity in PAH patients compared to controls, and this requires further study in larger samples.