Molecular Mechanisms Linking Adiponectin Receptor Signalling and Cancer
Atsushi Nakajima*, 1, Hiroki Endo1, Kyoko Yoneda1, Toshio Fujisawa1, Michiko Sugiyama1, Kunihiro Hosono1, Yuichi Nozaki1, Hirokazu Takahashi1, Koji Fujita1, Masato Yoneda1, Masahiko Inamori1, Takashi Shimamura1, Noritoshi Kobayashi1, Hiroyuki Kirikoshi1, Kensuke Kubota1, Satoru Saito1, Koichiro Wada2, Hitoshi Nakagama3
Identifiers and Pagination:Year: 2010
First Page: 43
Last Page: 49
Publisher Id: TOOBESJ-2-43
Article History:Received Date: 22/04/2009
Revision Received Date: 16/06/2009
Acceptance Date: 16/06/2009
Electronic publication date: 14/7/2010
Collection year: 2010
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Adiponectin is an adipose tissue-derived hormone. It is a key hormone that is responsible for insulin sensitization, and its circulating level is inversely associated with abdominal obesity. Recent studies have shown that a reduced plasma adiponectin level is significantly correlated with the risk of various kinds of cancers. Adiponectin may influence the cancer risk by modulating the metabolic environment indirectly. However several cancer cells express adiponectin receptors, suggesting that adiponectin also may modulate the cancer progression directly. Herein, we review the recent evidence concerning the molecular mechanisms linking adiponectin receptor signaling and cancer. Further studies are required to fully elucidate the molecular mechanisms of the adiponectin-mediated signaling pathway in cancer.