A Possible Role for Chemerin; a Novel Adipokine in the Haemostatic and Atherogenic Disorders Related to Obesity in White Albino Rats
Enas N. Morgana, b, Husam M. Edreesa, *
Identifiers and Pagination:Year: 2013
First Page: 65
Last Page: 71
Publisher Id: TOOBESJ-5-65
Article History:Received Date: 25/04/2013
Revision Received Date: 10/06/2013
Acceptance Date: 18/06/2013
Electronic publication date: 07/8/2013
Collection year: 2013
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A strong link between obesity, hypercoagulability and thrombogenesis, had been recognized. Chemerin is a novel adipokine that has been activated by the coagulation process and suggested to play an important role in the pathogenesis of metabolic syndrome. We aimed to identify the possible relationship between chemerin levels and haemostatic changes in the high fat diet (HFD) fed rats. A total number of 20 adult male albino rats were divided into two groups of 10 rats each. Group I, rats served as controls; Group II: rats received high fat diet (58% fat) for 8 weeks. In both groups, serum levels of glucose, insulin, chemerin, total cholesterol (TC), triglycerides (TG), HDL, LDL were measured. As well as the bleeding time (BT), whole blood clotting time (WBCT), Prothrombin time (PT), Activated partial thromboplastin time (aPTT), fibrinogen level and C- reactive protein (CRP) were measured. Moreover HOMA-IR was calculated for both groups. The results of the current study revealed that chemerine level increased significantly in the HFD- fed rats (p< 0.001). In addition, a significant positive correlation was detected for the serum chemerin levels with body weight, insulin levels, HOMA-IR, the levels of TC, TG, LDL and CRP, while a significant negative correlation was found between its levels and serum levels of HDL. Moreover chemerin was correlated negatively with the BT, WBCT, PT, aPTT and positively correlated with plasma fibrinogen, while there was insignificant correlation with platelet count. These results suggested that chemerin may represent a novel link between obesity and its haemostatic and atherogenic complication.