RESEARCH ARTICLE


Association of Changes in Body Composition with Changes in Systemic Oxidative Stress Following Weight Loss Program in Obese Adults Attending Obesity Clinic, Hospital Universiti Sains Malaysia



Md Rizman Md Lazin @ Md Lazim1, Rahimah Zakaria1, *, Rohana Abdul Jalil2, Wan Suriati Wan Nik3, Che Badariah Abdul Aziz1, Asma Hayati Ahmad1, Liza Noordin1, Ainul Bahiyah Abu Bakar1
1 Department of Physiology, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
2 Department of Community Medicine, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
3 Dietetics Program, School of Health Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia

Article Information


Identifiers and Pagination:

Year: 2014
Volume: 6
First Page: 60
Last Page: 64
Publisher Id: TOOBESJ-6-60
DOI: 10.2174/1876823701406010060

Article History:

Received Date: 24/07/2014
Revision Received Date: 08/09/2014
Acceptance Date: 12/09/2014
Electronic publication date: 17/10/2014
Collection year: 2014

© 2014 Lazim et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia; Tel/Fax: 609-7676156/609-7653370; E-mail: rahimah@usm.my


Abstract

The main objective of the present study was to evaluate the association of changes in body composition with changes in systemic oxidative stress markers among obese adults participating in a weight loss program. Thirty four obese adults were recruited from the Obesity Clinic, Hospital Universiti Sains Malaysia (USM) to voluntarily participate in a weight loss program comprising of physical exercise and dietary modification. Levels/activities of oxidative stress markers were measured before and after the program. Mean body weight, body mass index (BMI), waist circumference (WC), hip circumference (HC) and percentage of body fat mass decreased significantly while mean body lean mass and body water increased significantly after the weight loss program. Plasma glutathione peroxidase (GPx) activity and 4- hydroxynonenal (4-HNE) concentration increased significantly while other enzymatic antioxidant activities such as catalase (CAT) and superoxide dismutase (SOD) were not significantly increased. The ratio of reduced glutathione (GSH) to oxidized glutathione (GSSG) was significantly decreased. There was no significant association between changes in body composition and changes in systemic oxidative stress markers among obese adults. In conclusion, changes in body composition were not associated with changes in systemic oxidative stress markers among obese adults.

Keywords: Body composition, dietary, exercise, obesity, oxidative stress, weight loss program.