Developmental Origins of Obesity - Genetic and Epigenetic Determinants
Benjamin Rokholm*, #, Camilla Schou Andersen#, Thorkild I.A. SØrensen
Identifiers and Pagination:Year: 2011
First Page: 27
Last Page: 33
Publisher Id: TOOBESJ-3-27
Article History:Received Date: 31/07/2009
Revision Received Date: 28/08/2009
Acceptance Date: 10/11/2009
Electronic publication date: 01/3/2011
Collection year: 2011
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Childhood obesity is a major public health concern. The importance of genes in development of obesity is evident from twin and family studies. Moreover, epigenetic events in early life may play an important role in obesity etiology.
We aimed to outline and discuss the role of genetic and epigenetic influences on development of obesity in early life from around birth and into adolescence.
We included a series of interesting contributions on the area. First, the topic was addressed on the relative influence of genes and environment. Next, we turned to the significance of epigenetic events.
Genetic influences play an important role in individual differences in body fatness throughout childhood and adolescence, with an increasing heritability with age. In addition, environmental factors can influence the epigenetic regulation, making the individual more susceptible to develop obesity.
Our knowledge of genetic and epigenetic contributions to obesity development has increased dramatically during the last century. Future studies and technological advnces, will undoubtedly reveal even more complicated pathways that have to be considered when trying to prevent the dramatic worldwide increase in obesity.